ncRNA basic information
ncRNA ID:
MI0000060/MI0000061/MI0000062
ncRNA Database:
miRBase
ncRNA Name:
Let-7a
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00445 (APRD00361)
Drug Name:
epirubicin
Drug Method:
The expression levels of miRNA were determined by real-time quantitative reverse transcription PCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (SKBR3,SK-3rd)
Other information
Title:
Reduced Let-7a Is Associated with Chemoresistance in Primary Breast Cancer.
Journal:
PLoS One
Published:
2015
PubMed ID:
26218285