ncRNA basic information
ncRNA ID:
MI0000737
ncRNA Database:
miRBase
ncRNA Name:
miR-200a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
EGFR
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00317 (APRD00997, DB07998)
Drug Name:
Gefitinib
Drug Method:
The expression levels of miRNA were determined by RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. A wound healing assay and cell Invasion assay were performed to examine the capacity of cell migration.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line ( MRC-5, CCD-19Lu,H3255, H1975,HCC827)
Other information
Title:
MicroRNA-200a Targets EGFR and c-Met to Inhibit Migration, Invasion, and Gefitinib Resistance in Non-Small Cell Lung Cancer.
Journal:
Cytogenet Genome Res
Published:
2015
PubMed ID:
26184032