ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR,Northern blot
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
NA
Drug Name:
TRAIL therapy
Drug Method:
The expression levels of miRNA were determined by qRT-PCR and Northern blot . Those of protein were by Western blot analysis. Soft Agar Colony Formation Assay were performed to determine the in vitro tumorigenicity of the cells. Animal studies were used to test the role of microrna.
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (H460S/R, H292S/R, HEK293, Calu-1,A549)
Other information
Title:
A set of NF-kappaB-regulated microRNAs induces acquired TRAIL resistance in lung cancer.
Journal:
Proc Natl Acad Sci U S A
Published:
2015
PubMed ID:
26080425