ncRNA basic information
ncRNA ID:
MI0000448
ncRNA Database:
miRBase
ncRNA Name:
miR-130a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Real-time qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
We profiled miRNAs differentially expressed in cisplatin-resistant human ovarian cancer cell line A2780/DDP compared with parental A2780 cells using microarray. The expression levels of miRNA were determined by Real-time qRT-PCR and those of protein were by Western blot analysis. Potential targets of differentially expressed miRNAs were predicted with the help of PicTar or TargetScan .
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (A2780, A2780/DDP)
Other information
Title:
MiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 Cells.
Journal:
PLoS One
Published:
2015
PubMed ID:
26043084