ncRNA basic information
ncRNA ID:
MI0000446/MI0000470
ncRNA Database:
miRBase
ncRNA Name:
miR-125b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
p53
ncRNA Pathway:
p53 signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Soft agar assays were performed to determine the in vitro tumorigenicity of the cells. The CCK-8 assay was used to monitor the growth of the cells .
Drug Response:
sensitive
Cancer basic information
Cancer:
nasopharyngeal carcinoma
Tissue/Cell:
cell line (TW03, CNE-1, CNE-2 NPC,NP69)
Other information
Title:
Has-miR-125a and 125b are induced by treatment with cisplatin in nasopharyngeal carcinoma and inhibit apoptosis in a p53-dependent manner by targeting p53 mRNA.
Journal:
Mol Med Rep
Published:
2015
PubMed ID:
26017674