ncRNA basic information
ncRNA ID: MI0000446/MI0000470
ncRNA Database: miRBase
ncRNA Name: miR-125b
ncRNA Type: miRNA
ncRNA Expression: up-regulated
ncRNA Method: RT-qPCR
ncRNA Target Gene: p53
ncRNA Pathway: p53 signaling pathway
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB00515 (APRD00359)
Drug Name: Cisplatin
Drug Method: The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Soft agar assays were performed to determine the in vitro tumorigenicity of the cells. The CCK-8 assay was used to monitor the growth of the cells .
Drug Response: sensitive
Cancer basic information
Cancer: nasopharyngeal carcinoma
Tissue/Cell: cell line (TW03, CNE-1, CNE-2 NPC,NP69)
Other information
Title: Has-miR-125a and 125b are induced by treatment with cisplatin in nasopharyngeal carcinoma and inhibit apoptosis in a p53-dependent manner by targeting p53 mRNA.
Journal: Mol Med Rep
Published: 2015
PubMed ID: 26017674