ncRNA basic information
ncRNA ID:
MI0011285
ncRNA Database:
miRBase
ncRNA Name:
miR-2278
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
AKT2, STAM2, STAT5A
ncRNA Pathway:
JAK/STAT signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00619 (APRD01028, EXPT02967, DB03261)
Drug Name:
Imatinib
Drug Method:
The role of miR-2278 in leukemic cells was detected using qRT-PCR, western blot assay, apoptosis assays, Genome-wide microRNA array analysis, Genome-wide mRNA array analysis, miRNA validation and mRNA validation, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
chronic myeloid leukemia
Tissue/Cell:
cell line ( K562)
Other information
Title:
Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted hsa-miR-2278 as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A.
Journal:
Tumour Biol
Published:
2015
PubMed ID:
25953263