ncRNA basic information
ncRNA ID:
MI0000095
ncRNA Database:
miRBase
ncRNA Name:
miR-93
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by qRT-PCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic. Xenograft Tumor Growth was used to test the role of miR-93 .
Drug Response:
sensitive
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (C13,SKOV3)
Other information
Title:
Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells.
Journal:
Proc Natl Acad Sci U S A
Published:
2015
PubMed ID:
25831546