ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PDCD4
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01169 (APRD00171)
Drug Name:
Arsenic trioxide
Drug Method:
The expression levels of miRNA were determined by Real-time PCR and those of protein were by Western blot analysis,etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
chronic myelogenous leukemia (CML)
Tissue/Cell:
cell line ( K562 )
Other information
Title:
Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis.
Journal:
Cancer Sci
Published:
2010
PubMed ID:
20148895