ncRNA basic information
ncRNA ID: MI0000440
ncRNA Database: miRBase
ncRNA Name: miR-27b
ncRNA Type: miRNA
ncRNA Expression: up-regulated
ncRNA Method: qPCR
ncRNA Target Gene: CCNG1
ncRNA Pathway: p53 signaling pathway
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB00445 (APRD00361)
Drug Name: Epirubicin
Drug Method: Exploiting the multitarget characteristic of microRNAs (miRNAs), we developed a new therapeutic strategy by the combinational use of miRNA and anticancer drugs to increase drug response. By a systems approach, we identified that miR-27b, a miRNA deleted in liver and kidney cancers, sensitizes cancer cells to a broad spectrum of anticancer drugs in vitro and in vivo. Functionally, miR-27b enhances drug response by activating p53-dependent apoptosis and reducing CYP1B1-mediated drug detoxification.
Drug Response: sensitive
Cancer basic information
Cancer: liver cancer
Tissue/Cell: cell line (HepG2, HeLa, Tong,HEK-293FT,SNU-182, SNU-739, 769-P,786-O)
Other information
Title: miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression.
Journal: Cell Res
Published: 2015
PubMed ID: 25698578