ncRNA basic information
ncRNA ID:
MI0000270/MI0000683
ncRNA Database:
miRBase
ncRNA Name:
miR-181b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
TIMP3
ncRNA Pathway:
TGFBeta signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by Real-time reverse-transcription polymerase chain reaction (RT-PCR) and those of protein were by Western blot analysis. Cell migration was detected by transwell migration and invasion assay.Analysis of oncogenic potential of miR-181b in nude mice
Drug Response:
resistant
Cancer basic information
Cancer:
hepatocellular carcinoma
Tissue/Cell:
cell line ( HCC )
Other information
Title:
TGFBeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.
Journal:
Oncogene
Published:
2010
PubMed ID:
20023698