ncRNA basic information
ncRNA ID:
MIMAT0000431
ncRNA Database:
miRBase
ncRNA Name:
miR-140-5p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
Exploiting the multitarget characteristic of microRNAs (miRNAs), we developed a new therapeutic strategy by the combinational use of miRNA and anticancer drugs to increase drug response. By a systems approach, we identified that miR-27b, a miRNA deleted in liver and kidney cancers, sensitizes cancer cells to a broad spectrum of anticancer drugs in vitro and in vivo. Functionally, miR-27b enhances drug response by activating p53-dependent apoptosis and reducing CYP1B1-mediated drug detoxification.
Drug Response:
resistant
Cancer basic information
Cancer:
liver cancer
Tissue/Cell:
cell line (HepG2, HeLa, Tong,HEK-293FT,SNU-182, SNU-739, 769-P,786-O)
Other information
Title:
miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression.
Journal:
Cell Res
Published:
2015
PubMed ID:
25698578