ncRNA basic information
ncRNA ID:
MI0000266
ncRNA Database:
miRBase
ncRNA Name:
miR-10a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
Forty de novo patients with AML, 16 patients with non-malignant hematologic disease and three AML cell lines HL-60, U937 and HL-60/ADR were enrolled in this study, the MiR-10a expression in bone marrow mononuclear cells of above-mentioned patients and 3 AML cell lines was detected by TaqMan RT-PCR. The correlation of miR-10a with clinicopathological factors of AML patients was analyzed.
Drug Response:
resistant
Cancer basic information
Cancer:
acute myeloid leukemia (except M3)
Tissue/Cell:
cell line (HL-60,U937, HL-60 /ADR)
Other information
Title:
MicroRNA-10a expression in FAB different subtype of acute myeloid leukemia and its relationship with drug resistance
Journal:
Zhongguo Shi Yan Xue Ye Xue Za Zhi
Published:
2015
PubMed ID:
25687041