ncRNA basic information
ncRNA ID:
MI0000060/MI0000061/MI0000062
ncRNA Database:
miRBase
ncRNA Name:
let-7a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The role of let-7a in metastatic breast cancer cells was detected using quantitative real-time PCR, microarray analysis, western blotting, stable isotope labeling with amino acids in cell culture (SILAC), cell cycle analysis and doxorubicin experiment, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MDA-MB-231,WM239)
Other information
Title:
Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA.
Journal:
Oncotarget
Published:
2015
PubMed ID:
25669981