ncRNA basic information
ncRNA ID:
MI0000289/MI0000269
ncRNA Database:
miRBase
ncRNA Name:
miR-181a
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB04690
Drug Name:
Camptothecin
Drug Method:
BM samples were obtained from 18 patients where matched samples at initial diagnosis and first BM relapse or complete remission were available. BM samples and cord blood samples (normal controls) were used to confirm the differential expression of miRNA-181a by quantitative real-time polymerase chain reaction (qRT-PCR). The expressions of miR-181a in both CCRF-CEM and its mutidrug-resistant counterpart CEM-C1 cells were also detected. Then, CCK-8 assay was performed to quantify the effects of miR-181a on CEM-C1 and CCRF-CEM cells growth and viability.
Drug Response:
sensitive
Cancer basic information
Cancer:
pediatric acute lymphoblastic leukemia
Tissue/Cell:
cell line (CCRF-CEM,CEM-C1)
Other information
Title:
The expression and functional study of miR-181a in pediatric acute lymphoblastic leukemia
Journal:
Zhonghua Xue Ye Xue Za Zhi
Published:
2015
PubMed ID:
25641148