ncRNA basic information
ncRNA ID:
MI0000079
ncRNA Database:
miRBase
ncRNA Name:
miR-23a
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
NA
ncRNA Target Gene:
RUNX3
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The drug-resistant ovarian cancer A2780 cells were exposed to cisplatin alone or in combination with antagomir-23a. The cell inhibition rates after the treatments were detected using MTT assay, cell cycle changes assessed with flow cytometry; and apoptotic cells observed using Hoechst33258 staining. The changes in glycoprotein P-gp expression in the cells were detected using Western blotting.
Drug Response:
sensitive
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (A2780)
Other information
Title:
Inhibition of microRNA-23a increases cisplatin sensitivity of ovarian cancer cells: the possible molecular mechanisms
Journal:
Nan Fang Yi Ke Da Xue Xue Bao
Published:
2015
PubMed ID:
25613625