ncRNA basic information
ncRNA ID:
MIMAT0003389
ncRNA Database:
miRBase
ncRNA Name:
miR-542-3p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
PI3K-AKT pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00072 (BTD00098, BIOD00098)
Drug Name:
Trastuzumab
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (SKBR3, MCF7/HER2)
Other information
Title:
MiRNA-542-3p downregulation promotes trastuzumab resistance in breast cancer cells via AKT activation.
Journal:
Oncol Rep
Published:
2015
PubMed ID:
25586125