ncRNA basic information
ncRNA ID:
MIMAT0004494
ncRNA Database:
miRBase
ncRNA Name:
miR-21-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NAV3
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
We used microarrays to measure miRNA levels in the ovarian cancer cell line A2780 and its cisplatin-resistant derivative CP70. The role of miRNAs and the mRNA targets were tested using transfected miRNA mimics and siRNAs, respectively. Potential in vivo significance was investigated by analysing RNA levels in cohorts of ovarian cancer patients.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (A2780,CP70, OVCAR5, OVCAR8, IGROV1)
Other information
Title:
The passenger strand, miR-21-3p, plays a role in mediating cisplatin resistance in ovarian cancer cells.
Journal:
Gynecol Oncol
Published:
2015
PubMed ID:
25579119