ncRNA basic information
ncRNA ID:
MI0000439
ncRNA Database:
miRBase
ncRNA Name:
miR-23b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
HMGA2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of miRNA were determined by Methylation-specific PCR (MS-PCR) and stem-loop RT-PCR .Those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
glioma
Tissue/Cell:
cell line (U87)
Other information
Title:
Methylation mediated silencing of miR-23b expression and its role in glioma stem cells.
Journal:
Neurosci Lett
Published:
2012
PubMed ID:
22982144