ncRNA basic information
ncRNA ID:
MI0005564
ncRNA Database:
miRBase
ncRNA Name:
miR-873
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
CDK3
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The role of miR-873 in breast cancer cells was detected using Real-time PCR, chromatin immunoprecipitation, MTT assay, soft agar assay, co-immunoprecipitation, GST pull-down assay, Kinase assay, immunohistochemistry staining and animal experiments, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line ( MCF-7, ZR75-1, T47D, SKBR3, MDAMB-231, HEK293T,MCF-7/TamR)
Other information
Title:
MiR-873 regulates ERalpha transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells.
Journal:
Oncogene
Published:
2015
PubMed ID:
25531331