ncRNA basic information
ncRNA ID:
MI0002470/MI0023622
ncRNA Database:
miRBase
ncRNA Name:
miR-486
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
RFFL,EMP1,and DCBLD2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00619 (APRD01028, EXPT02967, DB03261)
Drug Name:
Imatinib
Drug Method:
The role of miR-486 in CML was detected using transduction and transfection of CD34+ cells,Cell proliferation, differentiation, cell cycle, and apoptosis assays, luciferase reporter, luciferase assays, western blot and immunodeficient mouse engraftment studies, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
chronic myeloid leukemia
Tissue/Cell:
cell line (293T, TF-1,TF-1-BA)
Other information
Title:
MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors.
Journal:
Blood
Published:
2015
PubMed ID:
25515961