ncRNA basic information
ncRNA ID:
MI0000109
ncRNA Database:
miRBase
ncRNA Name:
miR-103
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Cav-1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by quantitative real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Tumor xenograft studies was used to test the role of miR-103/107 .
Drug Response:
sensitive
Cancer basic information
Cancer:
gastric carcinoma
Tissue/Cell:
cell line ( SGC7901,SGC7901/ADR)
Other information
Title:
miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1.
Journal:
Tumour Biol
Published:
2015
PubMed ID:
25407491