ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
AKT pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of miR-21in A549/DDP human lung cancer cells was detected using quantitative PCR , antisense oligonucleotide transfection assay, cell viability detection assay, apoptosis and cell cycle assays, oxidative damage detection assay, cystathione and glutathione (GSH) detection assay, dual luciferase assay, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (A549, A549/DDP)
Other information
Title:
Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cells.
Journal:
Mol Med Rep
Published:
2015
PubMed ID:
25323306