ncRNA basic information
ncRNA ID:
MI0000749
ncRNA Database:
miRBase
ncRNA Name:
miR-30e
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ABL
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00619 (APRD01028, EXPT02967, DB03261)
Drug Name:
Imatinib
Drug Method:
The expression levels of miRNA were determined by real time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
chronic myeloid leukemia
Tissue/Cell:
cell line ( K562,HL-60,THP-1)
Other information
Title:
MiR-30e induces apoptosis and sensitizes K562 cells to imatinib treatment via regulation of the BCR-ABL protein.
Journal:
Cancer Lett
Published:
2015
PubMed ID:
25305453