ncRNA basic information
ncRNA ID:
MIMAT0000689
ncRNA Database:
miRBase
ncRNA Name:
miR-99b-5p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR,qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
An in-vitro model of acquired chemotherapy resistance in esophageal adeno- (EAC) and squamous cell carcinoma (ESCC) cells was used, and microRNA expression profiles for cisplatin or 5-fluorouracil (5-FU) resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction (PCR). The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.
Drug Response:
resistant
Cancer basic information
Cancer:
esophageal cancer
Tissue/Cell:
cell line (OE19,KYSE410)
Other information
Title:
MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines.
Journal:
World J Gastroenterol
Published:
2014
PubMed ID:
25356050