ncRNA basic information
ncRNA ID:
MIMAT0000281
ncRNA Database:
miRBase
ncRNA Name:
miR-224-5p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PRKCD
ncRNA Pathway:
PRKCD pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by qRT-PCR and those of protein were by Western blot analysis. Cellular apoptosis assay by assessing the activation of caspase-3 and -7, and with TUNEL . Computational approaches were used to analyze target prediction of miRNAs .
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian papillary serous carcinoma
Tissue/Cell:
tissue and cell line (A2780CP/A2780S, C13/OV2008)
Other information
Title:
Expression of miR-224-5p is associated with the original cisplatin resistance of ovarian papillary serous carcinoma.
Journal:
Oncol Rep
Published:
2014
PubMed ID:
25017423