ncRNA basic information
ncRNA ID:
MIMAT0000459
ncRNA Database:
miRBase
ncRNA Name:
miR-193a-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
LOXL4
ncRNA Pathway:
Oxidative Stress pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The expression levels of miRNA were determined by qRT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic.
Drug Response:
resistant
Cancer basic information
Cancer:
bladder cancer
Tissue/Cell:
cell line (5637,T24,UM-UC-3, Biu87)
Other information
Title:
miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the oxidative stress pathway.
Journal:
Mol Cancer
Published:
2014
PubMed ID:
25311867