ncRNA basic information
ncRNA ID:
MI0000466/MI0000467/MI0000468
ncRNA Database:
miRBase
ncRNA Name:
miR-9
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR,qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00773 (APRD00239)
Drug Name:
Etoposide
Drug Method:
miRNA microarrays are used to discover different expressions between different cell lines.The expression levels of miRNA were determined by RT-PCR and quantitative RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.Transfection of hsa-mir-326 miRIDIAN mimic and measurement of drug sensitivity.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
tissue and cell line (MCF-7/WT,MCF-7/VP,MCF-7/MX100)
Other information
Title:
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.
Journal:
Biochem Pharmacol
Published:
2010
PubMed ID:
19883630