ncRNA basic information
ncRNA ID:
MI0000650
ncRNA Database:
miRBase
ncRNA Name:
miR-200c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ZEB1
ncRNA Pathway:
PI3K/AKT and MEK/ERK pathways
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00317 (APRD00997, DB07998)
Drug Name:
Gefitinib
Drug Method:
The role of miR-200c in non-small cell lung cancer cells was detected using quantitative reverse-transcriptase polymerase chain reaction, MTT assay, western blot, immunocytochemistry and EGFR mutation analysis, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (PC9, PC9/R, H23, A549, H1975, H460, H1299)
Other information
Title:
miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type.
Journal:
Oncotarget
Published:
2014
PubMed ID:
25277203