ncRNA basic information
ncRNA ID:
MI0000103/MI0000739
ncRNA Database:
miRBase
ncRNA Name:
miR-101
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
EZH2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative reverse-transcriptase polymerase chain reaction analysis (qRT-PCR) and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Cell migration was detected by migration and invasion assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
epithelial ovarian cancer
Tissue/Cell:
cell line (A2780, SKOV3,A2780/DDP, SKOV3/DDP)
Other information
Title:
miR-101 regulates expression of EZH2 and contributes to progression of and cisplatin resistance in epithelial ovarian cancer.
Journal:
Tumour Biol
Published:
2014
PubMed ID:
25260883