ncRNA basic information
ncRNA ID:
MI0001648
ncRNA Database:
miRBase
ncRNA Name:
miR-449a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NOTCH1
ncRNA Pathway:
NOTCH pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by qRT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Flow cytometry analysis of cell apoptosis .
Drug Response:
sensitive
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line ( SKOV3, A2780,SKOV3/CDDP, A2780/CDDP)
Other information
Title:
MicroRNA-449a reduces cell survival and enhances cisplatin-induced cytotoxicity via downregulation of NOTCH1 in ovarian cancer cells.
Journal:
Tumour Biol
Published:
2014
PubMed ID:
25179844