ncRNA basic information
ncRNA ID:
MI0000294/MI0000295
ncRNA Database:
miRBase
ncRNA Name:
miR-218
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
real-time RT-PCR
ncRNA Target Gene:
mTOR
ncRNA Pathway:
mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
A miRNA microarray containing human mature and precursor miRNA sequences was used to compare expression profiles in serum samples of 5 patients with AGC before and after CRS + HIPEC. The upregulation of miR-218 was confirmed by real-time reverse transcription polymerase chain reaction and its expression was analyzed in SGC7901 gastric cancer cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (SGC7901)
Other information
Title:
MicroRNA-218 is upregulated in gastric cancer after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and increases chemosensitivity to cisplatin.
Journal:
World J Gastroenterol
Published:
2014
PubMed ID:
25170221