ncRNA basic information
ncRNA ID:
MI0000542
ncRNA Database:
miRBase
ncRNA Name:
miR-320a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
TRPC5 and NFATC3
ncRNA Pathway:
the TRPC5 signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The expression levels of miRNA were determined by quantitative Reverse-Transcription Polymerase Chain Reaction and Real-Time Polymerase Chain Reaction. Those of protein were by Western blot analysis.CpG plot online software was used to analyze CpGis on promoters.Immunohistochemical analysis was performed on TissueTek OCT-frozen sections using either TRPC5 or NFATC3 mAb (Abcam) .
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7/WT,HCT-8, MCF-7/ADM, MCF-7 PTX)
Other information
Title:
A methylation-based regulatory network for microRNA 320a in chemoresistant breast cancer.
Journal:
Mol Pharmacol
Published:
2014
PubMed ID:
25159093