ncRNA basic information
ncRNA ID:
MI0000650
ncRNA Database:
miRBase
ncRNA Name:
miR-200c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
HO-1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00398 (APRD01304, DB07438)
Drug Name:
Sorafenib
Drug Method:
The expression levels of miRNA were determined by quantitative PCR (qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
renal cell carcinoma
Tissue/Cell:
cell line (HEK293, SN12C, ACHN,786-O, Caki-1)
Other information
Title:
MiR-200c sensitizes clear-cell renal cell carcinoma cells to sorafenib and imatinib by targeting heme oxygenase-1.
Journal:
Neoplasma
Published:
2014
PubMed ID:
25150313