ncRNA basic information
ncRNA ID:
MI0000103/MI0000739
ncRNA Database:
miRBase
ncRNA Name:
miR-101
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
COX-2
ncRNA Pathway:
COX-2 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative polymerase chain reaction (qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Nude mouse xenografts was used to test the role of miR-101 .
Drug Response:
sensitive
Cancer basic information
Cancer:
bladder cancer
Tissue/Cell:
cell line (T24,T24/CDDP)
Other information
Title:
Enforced expression of miR-101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase-2 pathway.
Journal:
Mol Med Rep
Published:
2014
PubMed ID:
25109742