ncRNA basic information
ncRNA ID:
MI0003138
ncRNA Database:
miRBase
ncRNA Name:
miR-497
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PDCD4
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of miRNA were determined by Quantitative RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. ChIP assays were performed using the ChIP Assay kit . Apoptosis was measured using flow cytometry .
Drug Response:
resistant
Cancer basic information
Cancer:
glioma
Tissue/Cell:
cell line (U87, U251,HEK293T)
Other information
Title:
Hypoxia-induced miR-497 decreases glioma cell sensitivity to TMZ by inhibiting apoptosis.
Journal:
FEBS Lett
Published:
2014
PubMed ID:
25080009