ncRNA basic information
ncRNA ID:
MI0001733
ncRNA Database:
miRBase
ncRNA Name:
miRNA-452
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Adriamycin
Drug Method:
The expression levels of miRNA were determined by Real-time quantitative PCR (RT-qPCR) and those of protein were by Western blot analysis. RT-qPCR Analysis for Target Gene Expression . MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7,MCF-7/ADR)
Other information
Title:
Down-regulation of miRNA-452 is associated with adriamycin-resistance in breast cancer cells.
Journal:
Asian Pac J Cancer Prev
Published:
2014
PubMed ID:
25040964