ncRNA basic information
ncRNA ID:
MI0000650
ncRNA Database:
miRBase
ncRNA Name:
miR-200c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ZEB1,ZEB2
ncRNA Pathway:
p53 apoptotic pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by Quantitative reverse transcription real-time PCR (qRT-PCR) .Those of protein were by Western blot analysis.Cell migration was detected by t invasion assay.Cell survival analysis was used to assay drug sensitivity.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-10-2A, MCF-7, MDA-MB-361, HCC-70, T-47D, CAMA-1, Hs-578T, BT-549, and MDA-MB-231)
Other information
Title:
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells.
Journal:
Int J Cancer
Published:
2010
PubMed ID:
19839049