ncRNA basic information
ncRNA ID:
MI0000071
ncRNA Database:
miRBase
ncRNA Name:
miR-17
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
CDKN1A,p21
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by RT-PCR Luciferase activity assay was used to verify the target genes of miRNAs. Cell migration was detected by migration and invasion assay. Xenograft model was used to test the role of miR-17 .
Drug Response:
resistant
Cancer basic information
Cancer:
synovial sarcoma
Tissue/Cell:
cell line (SYO-1, Fuji, HS-SYII,HSC-2, HSC-3, HSC-4,LNCap,HT1080,Saos-2,293T)
Other information
Title:
SS18-SSX-regulated miR-17 promotes tumor growth of synovial sarcoma by inhibiting p21WAF1/CIP1.
Journal:
Cancer Sci
Published:
2014
PubMed ID:
24989082