ncRNA basic information
ncRNA ID:
MI0000268
ncRNA Database:
miRBase
ncRNA Name:
miR-34a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MET
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00317 (APRD00997, DB07998)
Drug Name:
Gefitinib
Drug Method:
The role of miR-34a in EGFR mutant lung cancer cells was detected using cell proliferation assay, cell apoptosis assay, Quantitative RT-PCR, ELISA, immunoblotting, vector construction and dual-luciferase reporter assay, animal experiments, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (HCC827,MRC-5,PC-9,HCC827 )
Other information
Title:
MicroRNA-34a overcomes HGF-mediated gefitinib resistance in EGFR mutant lung cancer cells partly by targeting MET.
Journal:
Cancer Lett
Published:
2014
PubMed ID:
24983493