ncRNA basic information
ncRNA ID:
MI0001446
ncRNA Database:
miRBase
ncRNA Name:
miR-424
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
PDCD4
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by real-time PCR and those of protein were by Western blot analysis. The CCK-8 assay was used to monitor the growth of the cells . TUNEL stining was used to detect apoptotic cell death. Xenograft tumor model was used to test the role of miR-424 .
Drug Response:
resistant
Cancer basic information
Cancer:
melanoma
Tissue/Cell:
cell line ( A375, U251, HCT116,HEK293T)
Other information
Title:
Hypoxia-induced miR-424 decreases tumor sensitivity to chemotherapy by inhibiting apoptosis.
Journal:
Cell Death Dis
Published:
2014
PubMed ID:
24967963