ncRNA basic information
ncRNA ID:
MI0000301
ncRNA Database:
miRBase
ncRNA Name:
miR-224
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
p21(WAF1/CIP1)
ncRNA Pathway:
p21(WAF1/CIP1)-pRb pathway,the intrinsic mitochondrial death pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
On the basis of miRNA microarray data, miR-224 was identified as the most upregulated miRNA in cisplatin (DDP; cis-diamminedichloroplatinum II)-resistant A549 cells compared with parental A549 cells. The aim of our study was to investigate the roles of miR-224 in the formation of DDP-resistant phenotype of LA cells and its possible molecular mechanisms.
Drug Response:
resistant
Cancer basic information
Cancer:
lung adenocarcinoma
Tissue/Cell:
tissue and cell line (A549,A549/DDP,SPC-A1,SPC-A1/DDP)
Other information
Title:
MiR-224 promotes the chemoresistance of human lung adenocarcinoma cells to cisplatin via regulating G-/S transition and apoptosis by targeting p21(WAF1/CIP1).
Journal:
Br J Cancer
Published:
2014
PubMed ID:
24921914