ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
real-time qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined byQuantitative real-time PCR (qRT-PCR) and those of protein were by Western blot analysis. The CCK-8 assay was used to monitor the growth of the cells . Animal experiments was used to test the role of miR-21.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (A549, SK-MES-1)
Other information
Title:
Downregulation of miR-21 increases cisplatin sensitivity of non-small-cell lung cancer.
Journal:
Cancer Genet
Published:
2014
PubMed ID:
24906642