ncRNA basic information
ncRNA ID:
MI0003814
ncRNA Database:
miRBase
ncRNA Name:
miR-1271
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
IGF1R,IRS1,mTOR,and BCL2
ncRNA Pathway:
IGF1R/IRS1 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative Real-Time Polymerase Chain Reaction and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line ( GES-1,MKN45, MGC803, BGC823,SGC7901,SGC7901/DDP)
Other information
Title:
miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2.
Journal:
Anticancer Agents Med Chem
Published:
2014
PubMed ID:
24875127