ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
PDCD4
ncRNA Pathway:
JNK-1/c-Jun pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of miR-21 in ovarian cance cells was detected using RNA isolation and cDNA synthesis, Polymerase Chain Reaction (PCR), SYBR-I-based real-time PCR, western blot, chromatin immunoprecipitation (ChIP), In vitro invasion assay, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (SKOV3ip1, HEYA8, A2780CP20,A2780, A2780CIS )
Other information
Title:
Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway.
Journal:
PLoS One
Published:
2014
PubMed ID:
24865582