ncRNA basic information
ncRNA ID:
MI0006326
ncRNA Database:
miRBase
ncRNA Name:
miR-1236
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
We analyzed the miRNA expression profiles to investigate the role of serum miRNA in predicting response to rituximab, cyclophosphamide, Adriamycin, vincristine, and prednisone (R-CHOP) treatment in diffuse large B cell lymphoma (DLBCL) patients. The present study proceeded through three phases. In the discovery phase, real-time polymerase chain reaction (PCR)-based miRNA profiling was used to test the difference in levels of serum miRNAs between 20 patients with complete remission after 6 cycles of R-CHOP treatment and 20 patients with primary refractory disease matched by age, sex, and stage. After the marker selection phase, the selected serum miRNAs were validated in 133 patients using the quantitative reverse transcriptase-PCR assays during the validation phases.
Drug Response:
resistant
Cancer basic information
Cancer:
diffuse large B-cell lymphoma
Tissue/Cell:
tissue
Other information
Title:
Serum microRNA expression profiling predict response to R-CHOP treatment in diffuse large B cell lymphoma patients.
Journal:
Ann Hematol
Published:
2014
PubMed ID:
24858372