ncRNA basic information
ncRNA ID:
NA
ncRNA Database:
miRBase
ncRNA Name:
miR-200
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR,RT-PCR
ncRNA Target Gene:
MIG6
ncRNA Pathway:
TGFBeta-miR200-MIG6 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00530 (APRD00951)
Drug Name:
Erlotinib
Drug Method:
The role of TGFBeta-miR200-MIG6 pathway in cancer cells was detected using reverse transcription and real-time PCR , cell viability assay , xenograft generation , etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
cancer
Tissue/Cell:
cell line (H226, H292, H358, H1838, A549, Calu6, H460, H1703, H1915, H1299, Calu3, H1437, H23,5637, SCaBER, UMUC-3, T24, HT-1376, BFTC-905, J82)
Other information
Title:
The TGFBeta-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors.
Journal:
Cancer Res
Published:
2014
PubMed ID:
24830724