ncRNA basic information
ncRNA ID:
MI0000743
ncRNA Database:
miRBase
ncRNA Name:
miR-34c
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Notch1,LEF1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by quantitative real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Cell migration was detected by transwell migration and invasion assay.
Drug Response:
resistant
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
cell line (MG-63, U2OS, HeLa)
Other information
Title:
MiR-34c inhibits osteosarcoma metastasis and chemoresistance.
Journal:
Med Oncol
Published:
2014
PubMed ID:
24802328