ncRNA basic information
ncRNA ID:
MI0000482
ncRNA Database:
miRBase
ncRNA Name:
miR-185
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by qRT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.TUNEL staining was used to detect apoptotic cell death. Subcutaneous tumor xenograft model was used to test the role of miR-185 .
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (GES-1,NCI-N87, MGC-803, BGC-823, AGS,)
Other information
Title:
MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain.
Journal:
Cell Death Dis
Published:
2014
PubMed ID:
24763054