ncRNA basic information
ncRNA ID:
MI0003178/MI0003182
ncRNA Database:
miRBase
ncRNA Name:
miR-519a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The role of miR-519a in ER+ breast cancer cells was detected using quantitative RT-PCR, cell viability and cell cycle assays, apoptosis assay, PI staining, miRNA target prediction, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line(MCF-7 WT,TamR,HEK-293FT,BT-474,CAMA-1)
Other information
Title:
MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer.
Journal:
J Pathol
Published:
2014
PubMed ID:
24752803