ncRNA basic information
ncRNA ID:
MI0000071
ncRNA Database:
miRBase
ncRNA Name:
miR-17
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
TGF-Beta signalling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Total RNA samples of A549 cells and A549/DDP cells were allowed to compare the miRNA expression by microarray assay. The expression levels of miRNA were determined by RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Cell migration was detected by transwell migration . The CCK-8 assay was used to monitor the growth of the cells .
Drug Response:
resistant
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (A549,A549/DDP)
Other information
Title:
MiRNA 17 family regulates cisplatin-resistant and metastasis by targeting TGFBetaR2 in NSCLC.
Journal:
PLoS One
Published:
2014
PubMed ID:
24722426